If we have kids, is there anything we can do medically to prevent the kids having SS genotype? (Sickle cell)?

sickle cell is a recessive trait that is carried on the X chromosome. so, unless you both have the trait, then your daughters will be fine. if the father has the trait, but not the mother, then the boy children could get the disease. there is nothing you can do to prevent this. take a blood test before having kids to see if you are both carriers.